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| Status |
Public on Aug 11, 2012 |
| Title |
The gene expression pattern of bone marrow mesenchymal stem cells from patients with psoriasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Object: To study the difference of gene expression pattern of bone marrow mesenchymal stem cells (BMMSCs) between psoriatic patients, normal adults and aborted fetuses, and then to explore the influence of bone marrow mesenchymal stem cells to immune system. Methods: Bone marrow mononuclear cells (BMMNC) of 7 psoriatic patients, 4 healthy volunteers and 3 aborted fetuses were isolated and the BMMSCs were cultured using the adherent method. Gene expression of 14 samples was detected by gene microarray and the different expressed genes were analysised by SAM software. Results: 654 differentially expressed genes (66 up regulated, 588 down regulated) were detected between the psoriatic patients and normal adults, which were enriched in immune response, chemotaxis and cell adhesion etc. 2020 differentially expressed genes (888 up regulated, 1132 down regulated) were detected between the aborted fetuses and normal adults. These genes were enriched in cell cycle, cell division, immune response and MHC class II antigen etc. Conclusion: The gene expression pattern such as immune response, chemotaxis was aberrant in psoriatic BMMNCs, which was consistent with aborted fetuses in some immune related genes.
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| Overall design |
Bone marrow mononuclear cells (BMMNC) of 7 psoriatic patients, 4 healthy volunteers and 3 aborted fetuses were isolated and the BMMSCs were cultured using the adherent method. Gene expression of 14 samples was detected by gene microarray and the different expressed genes were analyzed by SAM software.
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| Contributor(s) |
Hou R, Shen C, Yan X, Li J, Liu R, Jia Y, Dong F, Li X, Yang Y, Zhang K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 10, 2012 |
| Last update date |
Oct 11, 2016 |
| Contact name |
wang liang |
| E-mail(s) |
wangliangkexue@163.com
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| Organization name |
BioChainBJ
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| Street address |
7A North Yongchang Road BDA
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| City |
Beijing |
| ZIP/Postal code |
100176 |
| Country |
China |
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| Platforms (1) |
| GPL14550 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Probe Name Version) |
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| Samples (14)
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| GSM984046 |
Bone marrow mesenchymal stem cells from healthy subject,replicate 1 |
| GSM984047 |
Bone marrow mesenchymal stem cells from healthy subject,replicate 2 |
| GSM984048 |
Bone marrow mesenchymal stem cells from healthy subject,replicate 3 |
| GSM984049 |
Bone marrow mesenchymal stem cells from healthy subject,replicate 4 |
| GSM984050 |
Bone marrow mesenchymal stem cells from aborted fetus,replicate 1 |
| GSM984051 |
Bone marrow mesenchymal stem cells from aborted fetus,replicate 2 |
| GSM984052 |
Bone marrow mesenchymal stem cells from aborted fetus,replicate 3 |
| GSM984053 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 1 |
| GSM984054 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 2 |
| GSM984055 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 3 |
| GSM984056 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 4 |
| GSM984057 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 5 |
| GSM984058 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 6 |
| GSM984059 |
Bone marrow mesenchymal stem cells from psoriasis patient,replicate 7 |
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| Relations |
| BioProject |
PRJNA172422 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE40033_RAW.tar |
43.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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