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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 04, 2016 |
| Title |
Investigation of MET copy number in various cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
This experiment investigates In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models. The goal of this study was to examine the effects of AMG337 on proliferation in cancer cell lines with varying MET copy number, the hypothesis being that high-level focal MET amplification is required to confer MET oncogene addiction and AMG337 sensitivity.
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| Overall design |
Each of 21 cancer cell lines hybridized competitively against a pooled human male reference genomic DNA to determine CNV through array CGH.
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| Contributor(s) |
Hughes PE, Rex K, Caenepeel S, Yang Y, Zhang Y, Broome MA, Kha HT, Burgess T, Amore B, Kaplan-Lefko PJ, Moriguchi J, Werner J, Damore MA, Baker D, Choquette DM, Harmange J, Radinsky R, Kendall R, Dussault I, Coxon A |
| Citation(s) |
27196782 |
| Submission date |
Jan 29, 2016 |
| Last update date |
Aug 03, 2016 |
| Contact name |
Dan Baker |
| E-mail(s) |
bakerd@amgen.com
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| Phone |
805-447-1000
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| Organization name |
Amgen Inc.
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| Department |
Molecular Sciences
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| Street address |
1 Amgen Center Drive
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| City |
Thousand Oaks |
| State/province |
CA |
| ZIP/Postal code |
91320 |
| Country |
USA |
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| Platforms (1) |
| GPL19387 |
Agilent-021850 SurePrint G3 Human CGH Microarray (Probe Name version) |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA310283 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE77414_RAW.tar |
2.4 Gb |
(http)(custom) |
TAR (of TXT) |
| Processed data provided as supplementary file |
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