|
| Status |
Public on Jun 16, 2017 |
| Title |
ZEB1-regulated inflammatory phenotype in breast cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
This SuperSeries is composed of the SubSeries listed below.
Zinc finger E-box binding protein 1 (ZEB1) and ZEB2 induce epithelial-mesenchymal transition (EMT) and cancer progression. However, little is known about global picture of transcriptional regulation by ZEB1 and ZEB2. Here we identified an inflammatory phenotype regulated by ZEB1 using chromatin immunoprecipitation-sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) in basal type breast cancer cells, followed by gene set enrichment analysis (GSEA) of ZEB1-bound genes.
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| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
28618162 |
| Submission date |
Oct 26, 2016 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Daizo Koinuma |
| E-mail(s) |
d-koinuma@umin.ac.jp
|
| Organization name |
University of Tokyo
|
| Department |
Pathology
|
| Street address |
Hongo 7-3-1, Bunkyo-ku
|
| City |
Tokyo |
| ZIP/Postal code |
113-0033 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
|
| Samples (12)
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|
| This SuperSeries is composed of the following SubSeries:
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| GSE89203 |
ZEB1 binding sites in TGF-beta-stimulated MDA-231-D and Hs578T basal type breast cancer cell lines [ChIP-seq] |
| GSE89205 |
RNA-sequencing in TGF-beta treated MDA-231-D cells transfected with ZEB1/ZEB2 siRNAs [RNA-seq] |
| GSE98270 |
ZEB1 binding sites in TGF-beta-stimulated MCF7 breast cancer cell line |
| GSE98273 |
RNA-sequencing in MDA-231-D cells transfected with ZEB1 or ZEB2 siRNAs |
|
| Relations |
| BioProject |
PRJNA350678 |
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