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Generation and characterization of human iPSC-derived microglia-like cells for the use in drug discovery
PubMed Full text in PMC Similar studies SRA Run Selector
CD22 blockage restores age-related impairments of microglia surveillance capacity
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
iPSC-derived microglia carrying the TREM2 R47H/+ mutation are pro-inflammatory and promote synapse loss.
PubMed Similar studies Analyze with GEO2R
Expression data of iPS microglia treated with TREM2 agonist antibody
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo
PubMed Full text in PMC Similar studies
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [bulk RNA-seq]
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [scRNA-seq]
Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer’s pathology in vivo [RNA-seq]
PLCG2 Regulates Divergent Microglial Functions via TREM2-Dependent and -Independent Signaling
PubMed Similar studies SRA Run Selector
Off target expression data from iPSC derived microglia treated with APOE/TREM2 ASOs for 24h/48h. The iPSC cells are from a wild type donor (BIONi10C).
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Alzheimer’s disease neuroinflammatory risk genes can be targeted with RNase-H active antisense oligonucleotides in human microglia
IPSC-derived neuronal cultures expressing the Alzheimer's disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network
TREM2 regulates microglial lipid metabolism during aging in mice [RNA-Seq]
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
PubMed Similar studies
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [single-cell RNA-Seq]
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer’s disease
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer’s disease [7 months]
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer’s disease [15 months]
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