|
| Status |
Public on Jul 03, 2017 |
| Title |
Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
DTP heterochromatin in genomic repeat regions protects the population from drug-induced death.
|
| |
|
| Overall design |
Investigation of RNA expression changes in heterogenous parental populations as compared to drug treated and drugtolerant populations. Also included are TSA treated parental and drug-tolerant populations
|
| |
|
| Contributor(s) |
Tindell CA, Guler GD, Jhunjhunwala S, Classon M |
| Citation(s) |
28781121 |
| Submission date |
Jul 03, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Suchit Jhunjhunwala |
| E-mail(s) |
suchitj@gene.com
|
| Organization name |
Genentech
|
| Street address |
1 DNA Way, MS-444A
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (18)
|
| GSM2692580 |
2a: PC9DTP RNA-seq |
| GSM2692581 |
2b: PC9DTP RNA-seq |
| GSM2692582 |
2c: PC9DTP RNA-seq |
| GSM2692583 |
3a: PC9DTP+TSA (50nM, 5hours) RNA-seq |
| GSM2692584 |
3b: PC9DTP+TSA (50nM, 5hours) RNA-seq |
| GSM2692585 |
3c: PC9DTP+TSA (50nM, 5hours) RNA-seq |
| GSM2692586 |
5a: PC9+erlotinib (1uM, 24 hours) RNA-seq |
| GSM2692587 |
5b: PC9+erlotinib (1uM, 24 hours) RNA-seq |
| GSM2692588 |
5c: PC9+erlotinib (1uM, 24 hours) RNA-seq |
| GSM2692589 |
6a: PC9 +carboplatin (50uM,72h) RNA-seq |
| GSM2692590 |
6b: PC9 +carboplatin (50uM,72h) RNA-seq |
| GSM2692591 |
6c: PC9 +carboplatin (50uM,72h) RNA-seq |
| GSM2692592 |
7a: PC9+TSA (50nM ,5hours) RNA-seq |
| GSM2692593 |
7b: PC9+TSA (50nM ,5hours) RNA-seq |
| GSM2692594 |
7c: PC9+TSA (50nM ,5hours) RNA-seq |
|
| This SubSeries is part of SuperSeries: |
| GSE74180 |
Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures |
|
| Relations |
| BioProject |
PRJNA392914 |
| SRA |
SRP110994 |
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