GEO DataSets

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...

Organism:

Macaca fascicularis; synthetic construct

Type:

Protein profiling by protein array

Platform:

GPL30414

270 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; synthetic construct; Macaca fascicularis

Type:

Protein profiling by protein array; Other

Platforms:

GPL30414 GPL27885 GPL33775

1258 Samples

Download data

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...

Organism:

Macaca fascicularis; synthetic construct

Type:

Other

Platform:

GPL33775

261 Samples

Download data: XLSX

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...

Organism:

Macaca fascicularis; synthetic construct

Type:

Other

Platform:

GPL33775

261 Samples

Download data: XLSX

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...

Organism:

synthetic construct; Macaca fascicularis

Type:

Protein profiling by protein array

Platform:

GPL30414

270 Samples

Download data: XLSX

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...

Organism:

Macaca fascicularis; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL27885

196 Samples

Download data: XLSX

(Submitter supplied) Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb infection in the majority of those exposed is controlled in an asymptomatic form referred to as latent tuberculosis infection (LTBI). HIV is a well-known catalyst of reactivation of LTBI to active TB infection (ATB). more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10183

15 Samples

Download data: GPR

(Submitter supplied) Increasing evidence suggests that antibodies (Abs) can have protective roles in M. tuberculosis (Mtb) infection but knowledge of the most relevant protective antigens and epitopes in humans is limited. Using novel glycan arrays, we establish that human serum IgG induced against the M. tuberculosis (Mtb) capsular polysacharide arabinomannan (AM) in natural Mtb infection is highly heterogeneous in its binding specificity and differs in both its reactivity to oligosaccharide (OS) motifs within AM and its functions between BCG vaccination and/or controlled (latent) versus uncontrolled (TB) M. more...

Organism:

Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL27885

24 Samples

Download data: MEV, XLSX

(Submitter supplied) Transcriptional profiling of Mycobacterium tuberculosis H37Rv exposed to immune sera from C57/BL6 mice immunized with a conjugate of Bacillus anthracis protective antigen and arabinomannan vs. protective antigen alone

Organism:

Mycobacterium tuberculosis; Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platform:

GPL20887

3 Samples

Download data: MEV

(Submitter supplied) Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited. Using novel glycan arrays, we characterized a very high affinity monoclonal antibody P1AM25 to AM/LAM, determined this mAb recognized distinct glycan epitopes from other anti-AM/LAM mAbs reported.

Organism:

synthetic construct; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL32887

2 Samples

Download data: GPR, TXT, XLSX