GPL11154[Accession] - GEO DataSets

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Select item 2002191411.

Screen for genes showing synthetic lethality with NF2 in Schwannoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL11154
10 Samples

Download data

Series

Accession:: GSE219141

ID:: 200219141

Select item 2002191362.

Screen for genes showing synthetic lethality with NF2 in Schwannoma [Other]

(Submitter supplied) Neurofibromatosis Type II is a genetic condition caused by loss of the NF2 gene, resulting in activation of the YAP/TAZ pathway and recurrent growth of benign tumors from Schwann cells, the glia of the peripheral nervous system. Unfortunately, no pharmacological therapy is currently available for NFII. Here, we undertake a genome-wide CRISPR/cas9 screen to search for synthetic-lethal genes that, when inhibited, cause death of NF2 mutant cells but not NF2 wildtype cells. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE219136

ID:: 200219136

Select item 2002191353.

Screen for genes showing synthetic lethality with NF2 in Schwannoma [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: TXT

Series

Accession:: GSE219135

ID:: 200219135

Select item 2002335464.

Nuclear export is a limiting factor in eukaryotic mRNA metabolism

(Submitter supplied) The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by sequencing of RNA (SLAM-seq) in the nuclear and cytosolic compartments. We develop a model that reliably quantifies mRNA synthesis, nuclear export, and nuclear and cytosolic degradation rates on a genome-wide scale. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
34 Samples

Download data: CSV

Series

Accession:: GSE233546

ID:: 200233546

Select item 2002164945.

Impact of sunitinib resistance on clear cell renal cell carcinoma therapeutic sensitivity in vitro

(Submitter supplied) Sunitinib resistance creates a major clinical challenge for the treatment of advanced clear cell renal cell carcinoma (ccRCC) and functional and metabolic changes linked to sunitinib resistance are not fully understood. We sought to characterize the molecular and metabolic changes induced by the development of sunitinib resistance in ccRCC by developing and characterizing the transcriptome of two human ccRCC cell lines resistant to sunitinib.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE216494

ID:: 200216494

PubMed Full text in PMC Similar studies

Select item 2002629636.

Transcriptional profile of human monocyte-derived macrophages stimulated with Interleukin 27

(Submitter supplied) Interleukin 27 (IL-27) is a member of the IL-6 and/or IL-12 family that elicits both pro- and anti-inflammatory responses. Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Recent studies have reported that IL-27 also induces a robust antiviral response against diverse viruses, both in vitro and in vivo, suggest that IFNs and IL-27 share many similarities at the functional level. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE262963

ID:: 200262963

Analyze with GEO2R

Select item 2001895247.

Altered gene expression in multiple key pathways in MSCs from people with osteoporosis compared to people who do not have osteoporosis

(Submitter supplied) Osteoporosis is caused by imbalanced bone remodelling homeostasis and is highly prevalent in post-menopausal women. The impact of osteoporosis on mesenchymal stromal cells (MSCs) is a key area of research as they are the progenitors of osteoblasts and are therefore critical to bone homeostasis. TBioinformatic analysis of transcriptional profiling data revealed specific misregulation of genes involved in the processing and trafficking of cellular components, as well as downregulation of Neo1 which has an important role in controlling cell fate choice. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
14 Samples

Download data: XLSX

Series

Accession:: GSE189524

ID:: 200189524

Select item 2002616458.

Bulk RNA-Seq of actinic keratoses

(Submitter supplied) RNA-Seq was performed on 8 actinic keratoses (AK) to identify differentially expressed genes in AK vs normal skin and cutaneous squamous cell carcinoma

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: TXT

Series

Accession:: GSE261645

ID:: 200261645

Analyze with GEO2R

Select item 2002289349.

IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium

(Submitter supplied) Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic development, malignant transformation, and tumor progression, has also been implicated in a variety of retinal diseases, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and diabetic retinopathy. EMT of the retinal pigment epithelium (RPE), although important in the pathogenesis of these retinal conditions, is not well understood at the molecular level. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
13 Samples

Download data: CSV

Series

Accession:: GSE228934

ID:: 200228934

Select item 20017161810.

RNA-seq analysis CARM1 inhibitor Ellagic acid effect on MDA-MB-231 cells

(Submitter supplied) Ellagic acid is a kind of polyphenol lactone, which is widely found in various fruits and nuts. It’s the natural inhibitor of CARM1. Ellagic acid was reported to inhibit breast cancer growth and metastasis. But the mechanism of Ellagic acid has not been investivaged clearly in triple-negative breast cancer (TNBC). Our results indicate that direct inhibition of CDK4 by Ellagic acid limits breast cancer proliferation and metastasis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE171618

ID:: 200171618

Analyze with GEO2R SRA Run Selector

Select item 20013657811.

Super cChIP-seq, a robust and universal epigenetic profiling method using 10 cells

(Submitter supplied) ChIP-seq is the standard technique to characterize the genome-wide epigenomic modifications, which requires millions of cells as starting material. Although some methods have recently reported to be suitable for epigenomic profiling with a small number of cells, there are still no methods capable of profiling both histone modifications and DNA methylation with extremely low input. Here, we developed a new method by supplementing carrier materials of chemically modified epigenetic markers and dUPT-containing DNA fragments during ChIP procedures. more...

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL11154 GPL13112
32 Samples

Download data: BW

Series

Accession:: GSE136578

ID:: 200136578

SRA Run Selector

Select item 20023060212.

Overcoming Lineage Plasticity and AR-Targeted Therapy Resistance in ZNF397-Deficient Prostate Cancer via TET2 Inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL11154 GPL30173 GPL18573
51 Samples

Download data: BW, NARROWPEAK, TXT

Series

Accession:: GSE230602

ID:: 200230602

Select item 20023060113.

Overcoming Lineage Plasticity and AR-Targeted Therapy Resistance in ZNF397-Deficient Prostate Cancer via TET2 Inhibition [RNA-seq]

(Submitter supplied) Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage plasticity and therapy resistance remain poorly understood. We identified Zinc Finger Protein 397 (ZNF397) as a bona fide coactivator of the androgen receptor (AR), essential for the transcriptional program governing AR-driven luminal lineage. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE230601

ID:: 200230601

Analyze with GEO2R

Select item 20021508214.

The Myc-Associated Zinc Finger Protein (MAZ) controls STAT1-mediated antiviral response by reshaping epigenome [MeDIP-Seq]

(Submitter supplied) The objectives of this study are to understand the regulatory roles of MAZ in biological processes using the NGS-deriveed ChIP-seq, DNA-MEDIP-seq and RNA-seq data in HAP1 control cells and MAZ knockout cells. Our comparative analysis of these data generated from the HAP1 control and MAZ KO cells shows that MAZ is required for recruiting STAT1 to its target sites by reshaping epigenetic landscape in the human genome, thereby mediating antiviral response cells. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: BW

Series

Accession:: GSE215082

ID:: 200215082

Select item 20021508015.

The Myc-Associated Zinc Finger Protein (MAZ) controls STAT1-mediated antiviral response by reshaping epigenome [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: TXT

Series

Accession:: GSE215080

ID:: 200215080

Analyze with GEO2R

Select item 20017137216.

PDL1 triggered from binding eIF3I contributes to ameliorate diabetes associated wound healing defects by regulating IRS4

(Submitter supplied) We report the application of the transcriptome profiling (RNA-seq) for high-throughput profiling of PD-L1 overexpression in HaCaT cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE171372

ID:: 200171372

Analyze with GEO2R SRA Run Selector

Select item 20025252717.

All-Trans-Retinoic Acid Treatment of IDH Mutant Astrocytes

(Submitter supplied) Immortalized human astrocytes were stably transfected to express IDH1 R132H. These cells were treated with 1uM ATRA

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE252527

ID:: 200252527

Analyze with GEO2R

Select item 20022936218.

microRNA signature to support clinical-decision making in patients with suspected Obstructive Sleep Apnea

(Submitter supplied) Plasmatic microRNA sequencing was conducted in specific matched subgroups of subjects (n = 53) with and without OSA using HTG EdgeSeq miRNA WTA Assay technology.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
53 Samples

Download data: TXT

Series

Accession:: GSE229362

ID:: 200229362

Select item 20020060019.

Effects of KRAS (G13C) expression on transcriptome profiles assessed in HPCs differentiated from patient-derived iPS cells

(Submitter supplied) How a single oncogenic RAS impacts non-transformed hematopoietic progenitor cells (HPCs) remains largely unknown. We therefore investigated how a monoallelic KRAS mutation (G13C) affected HPCs utilizing induced pluripotent stem cells (iPSCs) derived from two unrelated patients with RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD).