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| Status |
Public on Nov 12, 2013 |
| Title |
Dataset #1 for genome-wide analysis of heritable dog osteosarcoma in 3 breeds |
| Organism |
Canis lupus familiaris |
| Experiment type |
SNP genotyping by SNP array
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| Summary |
Osteosarcoma in dogs is a spontaneously occurring disease with a global tumor gene expression signature indistinguishable from human pediatric tumors and clinical progression is remarkably similar. Unlike human OS, canine OS is a highly heritable disease with some large and giant dog breeds at >10x increased risk. We did a genome wide association study of osteosarcoma using the Illumina CanineHD genotyping array in three breeds: greyhound (mortality from OS = 26%), rottweiler (17%) and Irish wolfhound (IWH, 21%) and identified 33 inherited risk loci explaining 55 to 85% of phenotype variance in each breed.
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| Overall design |
Data created for a genome-wide association studio of heritable osteosarcoma risk factors in dogs, including 267 racing greyhounds (153 affected (A) + 114 unaffected (U)), 135 rottweilers (80 A + 55 U), 141 IWH (76 A + 65 U) and 19 AKC greyhounds using the Illumina CanineHD array (~170,000 SNPs genomewide)
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| Contributor(s) |
Karlsson E, Lindblad-Toh K |
| Citation(s) |
24330828 |
| Submission date |
Oct 31, 2013 |
| Last update date |
Feb 19, 2014 |
| Contact name |
Elinor Karlsson |
| E-mail(s) |
elinor@broadinstitute.org
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| Organization name |
Broad Institute
|
| Street address |
7 Cambridge Center
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
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| Samples (145)
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| This SubSeries is part of SuperSeries: |
| GSE52147 |
Genome-wide analysis of heritable dog osteosarcoma in 3 breeds |
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| Relations |
| BioProject |
PRJNA227157 |
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